the effect of exercise therapy on cognitive functions in multiple sclerosis patients: a pilot study

background: the positive impacts of exercise therapy on patients’ cognitive problems still remain unknown. this study was a pilot intervention to examine the effects of combined exercise on the cognitive problems of patients with multiple sclerosis (ms) in iranian ms society over 2012 to 2013.   methods : this quasi-experimental research was carried out in the form of a pretest/posttest study. forty two patients with ms were selected from those visiting the rehabilitation center of iranian ms society, using non-probability convenience sampling. the expanded disability status scale (edss) of each patient was recorded before the intervention and brief repeatable battery of neuropsychological (brb-n) test was administered before and after the intervention. the data were analyzed using the analytical tests such as wilcoxon test.   results : of 21 participants, 17 subjects (82%, n=14) female with mean (±sd) age of 37 (±9.98) years and mean (±sd) edss of 2.35 (±0.90) completed all stages of the study. changes in long-term storage and permanent long-term retrieval of information after the intervention were statistically significant (p< 0.001). in addition, the change in the average of total delay after the intervention was also significant by 1.11 (p< 0.001).   conclusion : our study confirmed the possibility of change in the cognitive abilities of ms patients through physical interventions. this finding emphasizes the necessity of more clinical examinations and increases the hopes for new rehabilitation methods for the disorder.